Lunchtime pandemic reading.
Standard disclaimer: this is a roundup of informative pieces I've read that interest me on the severity of the crisis and how to manage it. I am not a qualified medical expert in ANY sense; at best I am reasonably well-read laity. ALWAYS prioritize advice from qualified healthcare experts over some person on Facebook.
This is also available as an email newsletter at https://lunchtimepandemic.substack.com if you prefer the update in your inbox.
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Previously had COVID-19? You might need only one dose of the vaccine. "SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern. We investigated if single dose vaccination, with or without prior infection, confers cross protective immunity to variants. We analyzed T and B cell responses after first dose vaccination with the Pfizer/BioNTech mRNA vaccine BNT162b2 in healthcare workers (HCW) followed longitudinally, with or without prior Wuhan-Hu-1 SARS-CoV-2 infection. After one dose, individuals with prior infection showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351. By comparison, HCW receiving one vaccine dose without prior infection showed reduced immunity against variants. B.1.1.7 and B.1.351 spike mutations resulted in increased, abrogated or unchanged T cell responses depending on human leukocyte antigen (HLA) polymorphisms. Single dose vaccination with BNT162b2 in the context of prior infection with a heterologous variant substantially enhances neutralizing antibody responses against variants."
Source: https://science.sciencemag.org/content/early/2021/04/29/science.abh1282
Commentary: If it's available, fulfill the full dose regimen whether you've had COVID-19 or not, but this new research will enable nations to stretch vaccine supplies if supplies are limited. By testing vaccine recipients at time of vaccination for antibodies already in their blood, they can be told on the spot whether or not they need to come back for a second dose.
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Disinformation using influencer marketing. "Social media influencers in France with hundreds of thousands of followers say a mysterious advertising agency offered to pay them if they agreed to smear Pfizer’s COVID-19 vaccine with negative fake stories.
French YouTuber Léo Grasset was among those contacted. He said Tuesday that he was offered a potentially lucrative but also hush-hush deal to make bogus claims that Pfizer’s vaccine poses a deadly risk and that regulators and mainstream media are covering up the supposed dangers.
Grasset, who has 1.1 million subscribers on YouTube, says he refused. Other France-based influencers with sizable audiences on Twitter, Instagram and other platforms also said they were contacted with similar offers of payment for posts.
The person who contacted Grasset identified himself as Anton and said his agency has a “quite considerable” budget for what he described as an “information campaign” about “COVID-19 and the vaccines offered to the European population, notably AstraZeneca and Pfizer.”
Specifically, Anton asked for a 45- to 60-second video on Instagram, TikTok or YouTube to say that “the mortality rate of the Pfizer vaccine is 3 times greater than the AstraZeneca” and querying why the European Union is buying it.
“This is a monopoly and is causing harm to public health,” Anton claimed of EU’s purchases.
He refused in a follow-up email to divulge who is financing the disinformation campaign, saying: “The client prefers to remain incognito.”"
Source: https://apnews.com/article/europe-social-media-coronavirus-pandemic-business-coronavirus-vaccine-c4ce42244be08d7d73a412dd42e36360
Commentary: It makes you wonder [a] who is behind the campaign and [b] how many influencers in other nations have taken the bait. Be careful who you trust for valid scientific and medical information!
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Had COVID-19? Your first mRNA dose will have stronger side effects than someone who hasn't had COVID-19. "In a cohort of BNT162b2 (Pfizer–BioNTech) mRNA vaccine recipients (n = 1,090), we observed that spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses elicited by a single vaccine dose in individuals with prior SARS-CoV-2 infection (n = 35) were similar to those seen after two doses of vaccine in individuals without prior infection (n = 228). Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose."
Source: https://www.nature.com/articles/s41591-021-01325-6
Commentary: This makes logical sense; the first dose is the body's introduction to the SARS-CoV-2 spike protein for people who haven't had COVID-19, but for people who have, it's a reintroduction that prompts the same vigorous immune response that people get in their second dose. It's also worth noting that it's possible - possible, not a proven fact - that people who have stronger reactions to the first dose than the second dose of mRNA vaccines MAY have been exposed to COVID-19 asymptomatically, or in such a mild case that they didn't notice.
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A reminder of the simple daily habits we should all be taking.
1. Wear the best mask available to you when you'll be around other people, even after you've been vaccinated. Respirators are back in stock at online retailers, too. Wear an N95/FFP2/KN95 that's NIOSH-approved or better mask if you can obtain it. If you can't get an N95 mask, wear a surgical mask with a cloth mask over it.
2. Get vaccinated as soon as you're able to, and fulfill the full vaccine regimen. Remember that you are not vaccinated until everyone you live with is vaccinated.
3. Wash/sanitize your hands every time you are in or out of your home.
4. Stay home as much as practical. Minimize your contact with others and avoid indoor places as much as you can; indoor spaces spread the disease through aerosols and distance is less effective at mitigating your risks.
5. Get your personal finances in order now. Cut all unnecessary costs.
6. Replenish your supplies as you use them. Avoid reducing your stores to pre-pandemic levels in case an outbreak causes unexpected supply chain disruptions.
7. Ventilate your home as frequently as weather and circumstances permit, except when you share close airspaces with other residences (like a window less than a meter away from a neighboring window).
8. Masks must fit properly to work. Here's how to properly fit a mask:
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Common misinformation debunked!
There is no basis in fact that COVID-19 vaccines can shed or otherwise harm people around you.
Source: https://www.reuters.com/article/factcheck-covid19vaccine-reproductivepro-idUSL1N2MG256
There is no mercury or other heavy metals in the Pfizer mRNA vaccine.
Source: https://www.technologyreview.com/2020/12/09/1013538/what-are-the-ingredients-of-pfizers-covid-19-vaccine/
There is no basis in fact that COVID-19 vaccines pose additional risks to pregnant women.
Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2104983
There is no genomic evidence at all that COVID-19 arrived before 2020 in the United States and therefore no hidden herd immunity:
Source:
There is no evidence SARS-CoV-2 was engineered, nor that it escaped a lab somewhere.
Source: https://www.washingtonpost.com/world/2020/01/29/experts-debunk-fringe-theory-linking-chinas-coronavirus-weapons-research/
Source: https://www.nature.com/articles/s41591-020-0820-9
Source: https://www.nationalgeographic.com/science/2020/05/anthony-fauci-no-scientific-evidence-the-coronavirus-was-made-in-a-chinese-lab-cvd/
There is no evidence a flu shot increases your COVID-19 risk.
Source: https://www.factcheck.org/2020/04/no-evidence-that-flu-shot-increases-risk-of-covid-19/
Source: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa626/5842161
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Disclosures and Disclaimers
To be clear, I declare no competing interests on anything I share related to COVID-19. I am employed by and am a co-owner in TrustInsights.ai, an analytics and management consulting firm. I have no clients and no business interests in anything related to COVID-19, nor do I financially benefit in any way from sharing information about COVID-19.
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A common request I'm asked is who I follow. Here's a public Twitter list of many of the sources I read.
https://twitter.com/i/lists/1260956929205112834
This list is biased by design. It is limited to authors who predominantly post in the English language. It is heavily biased towards individual researchers and away from institutions. It is biased towards those who publish or share research, data, papers, etc. I have made an attempt to follow researchers from different countries, and also to make the list reasonably gender-balanced, because multiple, diverse perspectives on research data are essential.
This is also available as an email newsletter at https://lunchtimepandemic.substack.com if you prefer the update in your inbox.